Adherence to Clinical Practice Guidelines for the Treatment of Candidemia at a Veterans Affairs Medical Center

  • Chester N. Ashong Michael E. DeBakey Veterans Affairs Medical Center
  • Andrew S. Hunter Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine
  • M. David Mansouri Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine
  • Richard M. Cadle Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine
  • Richard J. Hamill Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine
  • Daniel M. Musher Michael E. DeBakey Veterans Affairs Medical Center Baylor College of Medicine
Keywords: Candidemia, Candida infections, Veterans Affairs

Abstract

Objectives: The primary objective of this study was to examine the appropriateness of candidemia management at a Veterans Affairs Medical Center as recommended by the 2009 Infectious Diseases Society of America (IDSA) guidelines for treatment of Candida infections.

Methods: A retrospective analysis of 94 adult patients with blood cultures positive for Candida spp. was performed. Patients were stratified by severity of disease into two groups: non-neutropenic, mild-moderate disease (Group 1, n = 54, 56%) and non-neutropenic, moderate-severe disease (Group 2, n = 40, 42%).

Results: Adherence to the IDSA recommendations for recommended antifungal drug, dose, and duration of therapy was low in both groups (16.7% in Group 1 and 17.5% in Group 2). Although adherence was not associated with higher clinical resolution of infection (P = 0.111), it was associated with a significantly lower mortality rate (P = 0.001) when compared to variance from the guidelines at 6 weeks.

Conclusion: Although adherence to published guidelines for treating patients with candidemia was suboptimal at our institution, patients that were managed based on the guidelines had a statistically lower mortality rate.

Published
2017-09-07
How to Cite
Ashong, C., Hunter, A., Mansouri, M., Cadle, R., Hamill, R., & Musher, D. (2017, September 7). Adherence to Clinical Practice Guidelines for the Treatment of Candidemia at a Veterans Affairs Medical Center. International Journal of Health Sciences, 11(3). Retrieved from https://ijhs.org.sa/index.php/journal/article/view/1883
Section
Original Paper