Meta-analysis reveals no correlation of caveolin-1 G14713A (G>A) gene polymorphism with increased cancer risk in Taiwanese population

  • Raju K Mandal Research and Scientific Studies Unit College of Nursing and Allied Health Sciences Jazan University Jazan-45142, Saudi Arabia
  • Mohammad Raish Department of Pharmacy, Kaohsiung Medical University, Gushan District No. 70 Lin sea Kaohsiung, Taiwan, R.O.C. Department of Pharmaceutics, College of Pharmacy, P.O. Box: 230155, King Saud University, Riyadh 11321, Saudi Arabia
  • Arshad Jawed Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
  • Mohd Wahid Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
  • Sajad A Dar Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
  • Mohtashim Lohani Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
  • Md. Ekhlaque Ahmed Khan Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India
  • Mohammed Y Areeshi Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
  • Naseem Akhter Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha-65431, Saudi Arabia
  • Saif Khan Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha’il, Ha’il-2440, Saudi Arabia
  • Shafiul Haque Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia
Keywords: Cancer, caveolin-1, genetic models, meta-analysis, polymorphism

Abstract

Objectives: The role of caveolin-1 (CAV1)(G>A, rs3807987) polymorphism is still dubious in cancer causation in Taiwanese population. The present study is an effort to assess the above relation for precise conclusion.

Methods: EMBASE and PubMed (MEDLINE) databases were explored for the pertinent case–control studies reporting the connection of CAV1 G14713A polymorphism to the vulnerability to cancer. A cumulative analysis using meta-analytic approach was accomplished and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for all the polymorphs.

Results: Overall, 2549 subjects and 3161 controls were analyzed from six selected studies. Our study showed no confirmation of noteworthy risk between CAV1 G14713A polymorphism and susceptibility to cancer in any of the polymorph, for instance, allele (A vs. G: P = 0.165; OR = 1.252, 95% CI = 0.911–1.721), homozygous (AA vs. GG: P = 0.252; OR = 1.328, 95% CI = 0.817–2.157), heterozygous (AG vs. GG: P = 0.091; OR = 1.356, 95% CI = 0.952–1.930), dominant (AA vs. GG + AG: P = 0.345; OR = 1.191, 95% CI = 0.829–1.709), and recessive (AA + AG vs. GG: P = 0.125; OR = 1.344, 95% CI = 0.921–1.961).

Conclusions: We conclude that CAV1 G14713A polymorphism does not contribute as an independent predisposing risk factor for developing cancer in Taiwanese population.

Author Biographies

Raju K Mandal, Research and Scientific Studies Unit College of Nursing and Allied Health Sciences Jazan University Jazan-45142, Saudi Arabia

Assistant Professor

Research and Scientific Studies Unit

College of Nursing and Allied Health Sciences

Jazan University

Jazan-45142, Saudi Arabia

Mohammad Raish, Department of Pharmacy, Kaohsiung Medical University, Gushan District No. 70 Lin sea Kaohsiung, Taiwan, R.O.C. Department of Pharmaceutics, College of Pharmacy, P.O. Box: 230155, King Saud University, Riyadh 11321, Saudi Arabia

Assitant Professor, Department of Pharmaceutics, College of Pharmacy, P.O. Box: 230155, King Saud University, Riyadh 11321, Saudi Arabia

Arshad Jawed, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Assistant Professor

Research and Scientific Studies Unit

College of Nursing and Allied Health Sciences

Jazan University

Jazan-45142, Saudi Arabia

Mohd Wahid, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Assistant Professor

Research and Scientific Studies Unit

College of Nursing and Allied Health Sciences

Jazan University

Jazan-45142, Saudi Arabia

Sajad A Dar, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Assistant Professor

Research and Scientific Studies Unit

College of Nursing and Allied Health Sciences

Jazan University

Jazan-45142, Saudi Arabia

Mohtashim Lohani, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Professor,

Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Md. Ekhlaque Ahmed Khan, Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India

Research Scholar,

Centre for Life Sciences, Central University of Jharkhand, Brambe, Ranchi-835205, Jharkhand, India

Mohammed Y Areeshi, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Dean & Associate Professor,

Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Naseem Akhter, Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha-65431, Saudi Arabia

Assistant Professor, Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha-65431, Saudi Arabia

Saif Khan, Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha’il, Ha’il-2440, Saudi Arabia

Assistant Professor,

Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha’il, Ha’il-2440, Saudi Arabia

Shafiul Haque, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Associate Professor & Unit Head

Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia

Published
2018-04-19
How to Cite
Mandal, R., Raish, M., Jawed, A., Wahid, M., Dar, S., Lohani, M., Khan, M. E., Areeshi, M., Akhter, N., Khan, S., & Haque, S. (2018). Meta-analysis reveals no correlation of caveolin-1 G14713A (G>A) gene polymorphism with increased cancer risk in Taiwanese population. International Journal of Health Sciences, 12(3). Retrieved from https://ijhs.org.sa/index.php/journal/article/view/2117
Section
Original Paper